Peptic ulcer disease
Peptic ulcer disease
Peptic ulcer is the ulceration within the GIT mucosa as a result of excessive secretion of gastric acid.
Common sites for peptic ulcer disease are stomach and duodenum.
Common causes
- H pylori infection
- NSAIDs
- Hypercalcemia
- Cirrhosis
- Renal failure
- Cigarette smoking
- Hypersecretory conditions such as gastrinoma
- Chronic obstructive pulmonary disease
Symptoms
- Upper abdominal pain after taking meals
- Pain radiating to the back
- Bleeding ulcer causes blood in vomiting or black stool
- Severe abdominal pain in presence of ulcer perforation
Diagnosis
- Upper GI endoscopy is indicated for peptic ulcers
- Biopsy to determine presence of H. pylori in the gastric antrum
Treatment
- Proton Pump Inhibitors (PPI)
- H pylori eradication