Chronic Hepatitis C

Chronic Hepatitis C

Hepatitis C is a virus which leads to chronic hepatitis, and leads to slowly progressive damage of liver, ultimately resulting in cirrhosis and liver cancer

Route and transmission of virus

  • Transfusion of contaminated blood prodcuts
  • Sharing of needle by untrained health care workers
  • Sharing of needle amongst drug abusers

Symptoms depend upon the stage of the disease

  • Patient may be totally asymptomatic, diagnosed on screening blood tests
  • Patient with chronic hepatitis may complain of fatigue
  • Patients with advanced liver disease may complain of ascites (fluid in abdomen), feet swelling, vomitinig of blood, change in behavior


Following test are done for diagnosis of chronic hepatitis C

  • LFT
  • Anti HCV antibody
  • HCV RNA, quantitative and qualitative

Treatment depends upon stage of liver disease and genotype of virus

  • Genotype 1 usually requires treatment for 48 weeks with PEG IFN and Ribavarin, Efficacy of treatment is around 50%
  • Genotype 2 and 3 are easy to treat, treatment response is 70-90%, and the duration of treatment is 24 weeks
  • Response rate in previously non responders has improved with addition of Telaprevir and Boceprevir to the Peg Interferon and Ribavarin
  • Recently trail for Sofosbuvir and Ribavarin had shown that injection free treatment without side effect will be available in near future
Emergency Cases

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