Non alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease is fat accumulation within the liver, without any history of alcohol consumption.
The liver has some amount of fat however, if the fat amount increases > 10% of liver weight it is indicative of fatty liver disease.
NAFLD presents with different severity:
- Fatty liver
- NASH (fatty liver with inflammation)
Deposition of fat in the liver. It is the most benign disease with minimum risk of disease progression.
NASH presents with fat deposition along with liver inflammation
There is a greater risk for progressive liver diseases
Cirrhosis is the most severe manifestation of NAFLD
Diagnosis of NAFLD
- FBS/serum insulin
- Lipid profile
- Thyroid profile
- USG abdomen shows hyperechoic liver and enlarged liver
- Liver biopsy if patients have a persistent elevation of liver enzymes
- Gradual weight reduction
- Lifestyle modification
- Minimize calorie intake
- Recent treatment included ursodeoxycholic acid and Vit E