Liver & Gallbladder Conditions
Comprehensive clinical protocols for Fatty Liver (NAFLD/NASH), Liver Cirrhosis, Viral Hepatitis, and Gallbladder/CBD Stones. Overseen by University Gold Medalist Dr. Ankita Gupta at GLEC, Greater Kailash-I, New Delhi.
Fatty Liver Disease (NAFLD & NASH)
Non-Alcoholic Fatty Liver Disease (NAFLD) occurs when excess fat builds up in liver cells (steatosis). If untreated, it can advance to NASH (inflammation) and progressive fibrosis.
Symptoms & Warning Signs
- Chronic fatigue, sluggishness, and midday exhaustion
- Dull ache or fullness in right upper abdomen
- Elevated liver enzymes (SGPT / SGOT) on routine blood test
- Often completely silent with zero noticeable symptoms until advanced
GLEC Diagnostic Workup
- In-House Fibroscan (CAP score for fat percentage + kPa for liver stiffness)
- High-Resolution Abdominal Ultrasound
- Comprehensive Liver Function Tests (LFT) & Lipid Profile
- Metabolic screening for insulin resistance and diabetes
Treatment & Protocol
- Quantitative Fibroscan fat score monitoring every 6 months
- Clinically structured hepatoprotective dietary protocol
- Targeted metabolic stabilization and insulin sensitizers
- Gradual 7-10% body weight loss to reverse steatosis
Liver Cirrhosis & Ascites
Cirrhosis represents permanent scarring and stiffening of liver tissue from prolonged inflammation. Complications include fluid accumulation in the abdomen (ascites) and portal hypertension.
Symptoms & Warning Signs
- Swelling in abdomen (ascites) and lower legs (pedal edema)
- Yellowing of skin and eyes (jaundice)
- Vomiting of blood (hematemesis) or dark black stools (melena)
- Confusion, forgetfulness, or sleep-cycle reversal (hepatic encephalopathy)
- Easy bruising and bleeding tendencies
GLEC Diagnostic Workup
- Transient Elastography (Fibroscan) kPa stiffness grading
- Diagnostic abdominal paracentesis (fluid analysis for infection/SBP)
- Screening Endoscopy for esophageal varices
- Multiphasic CT/MRI abdomen to monitor for hepatocellular carcinoma
Treatment & Protocol
- Endoscopic Variceal Band Ligation (EVL) to stop bleeding
- Salt-restricted nutrition and targeted diuretic therapy
- Antiviral or etiology-specific arrest of active liver damage
- Comprehensive pre-transplant assessment and stabilization
Chronic Hepatitis B & C
Viral hepatitis B and C cause long-standing silent liver inflammation that can quietly progress to cirrhosis or liver cancer over decades if left unmonitored.
Symptoms & Warning Signs
- Flu-like symptoms, low-grade fever, joint pains
- Mild nausea, loss of appetite, aversion to oily foods
- Persistent fatigue and reduced stamina
- Late signs: dark urine, clay-colored stools, jaundice
GLEC Diagnostic Workup
- Hepatitis B Surface Antigen (HBsAg) & Anti-HCV antibody test
- Quantitative Viral Load (HBV DNA / HCV RNA PCR)
- Fibroscan assessment to stage existing liver fibrosis
- Family and household screening protocols
Treatment & Protocol
- Direct-Acting Antivirals (DAAs) for Hepatitis C with >95% cure rates
- Long-term potent oral antivirals (Tenofovir / Entecavir) for Hepatitis B
- Every 6-month ultrasound and AFP screening for liver cancer prevention
- Vaccination guidance for uninfected family members
Gallbladder & Common Bile Duct (CBD) Stones
Gallstones form when bile hardens into crystal-like stones. If a stone slips out into the common bile duct, it obstructs bile flow, triggering severe biliary colic, jaundice, or acute pancreatitis.
Symptoms & Warning Signs
- Sudden, intense cramping pain in right upper abdomen radiating to back
- Pain typically triggered after eating heavy or fatty meals
- Nausea, bilious vomiting, and high-grade fever with chills
- Yellowish discoloration of eyes (obstructive jaundice)
GLEC Diagnostic Workup
- High-definition ultrasound of gallbladder and biliary tree
- MRCP (Magnetic Resonance Cholangiopancreatography)
- Serum Bilirubin, Alkaline Phosphatase, and Pancreatic Enzymes
Treatment & Protocol
- Emergency ERCP (Endoscopic Retrograde Cholangiopancreatography) to extract CBD stones without open surgery
- Sphincterotomy and biliary stent placement for jaundice drainage
- Referral for elective laparoscopic cholecystectomy for gallbladder clearance
- Complete avoidance of life-threatening cholangitis and pancreatitis
Alcoholic Liver Disease (ALD)
Regular heavy alcohol consumption causes a progressive spectrum of liver damage: from alcoholic fatty liver to acute alcoholic hepatitis and irreversible alcoholic cirrhosis.
Symptoms & Warning Signs
- Loss of appetite, morning nausea, and persistent fatigue
- Upper right quadrant abdominal tenderness and liver enlargement
- Severe jaundice, high fever, and abdominal fluid accumulation
- Tremors, altered sleep patterns, and memory lapses
GLEC Diagnostic Workup
- Liver Function Tests (AST typically twice the level of ALT)
- Ultrasound and Fibroscan quantification of liver fibrosis
- Nutritional and vitamin deficiency profiling
Treatment & Protocol
- Strict medically supervised alcohol cessation protocols
- High-protein, high-calorie clinical nutrition and micronutrient repletion
- Corticosteroid therapy for severe acute alcoholic hepatitis
- Silymarin, UDCA, and antioxidant support for cell membrane stabilization
Liver Tumors & Cholangiocarcinoma
Liver tumors may be benign (hemangioma, adenoma) or malignant (Hepatocellular Carcinoma / HCC or Cholangiocarcinoma of the bile ducts). Early detection is critical for curative outcomes.
Symptoms & Warning Signs
- Unexplained, rapid weight loss and severe loss of appetite
- Persistent dull pain or palpable mass in upper right belly
- Sudden worsening of jaundice in an already cirrhotic patient
- Itching, pale clay stools, and dark amber urine
GLEC Diagnostic Workup
- Triple-phase contrast CT or dynamic liver MRI
- Serum Alpha-Fetoprotein (AFP) and CA 19-9 tumor markers
- Endoscopic Ultrasound (EUS) and spyglass cholangioscopy biopsy
- Multidisciplinary tumor board evaluation
Treatment & Protocol
- Surgical resection or liver transplantation for early localized lesions
- Transarterial Chemoembolization (TACE) and Radiofrequency Ablation (RFA)
- Endoscopic biliary stenting to relieve bile duct blockages
- Targeted immunotherapy and systemic oncological care
